Heart rate variability regression and risk of sudden unexpected death in epilepsy

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• 作者：Alessio Galli ; ^{aleg170389@gmail.com} ; Federico Lombardi
• 关键词：SUDEP ; sudden unexpected death in epilepsy ; HRV ; heart rate variability
• 刊名：Medical Hypotheses
• 出版年：2017
• 出版时间：February 2017
• 年：2017
• 卷：99
• 期：Complete
• 页码：49-52
• 全文大小：237 K
• 卷排序：99

文摘

The exact mechanisms of sudden unexpected death in epilepsy remain elusive, despite there is consensus that SUDEP is associated with severe derangements in the autonomic control to vital functions as breathing and heart rate regulation. Heart rate variability (HRV) has been advocated as biomarker of autonomic control to the heart. Cardiac dysautonomia has been found in diseases where other branches of the autonomous nervous system are damaged, as Parkinson disease and multiple system atrophy. In this perspective, an impaired HRV not only is a risk factor for sudden cardiac death mediated by arrhythmias, but also a potential biomarker for monitoring a progressive decline of the autonomous nervous system. This slope may lead to an acute imbalance of the regulatory pathways of vital functions after seizure and then to SUDEP.