A multi-omic approach to elucidate low-dose effects of xenobiotics in zebrafish (Danio rerio) larvae

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• 作者：Susie S.Y. Huang^a ; ^b ; ^{shuang@axys.com} ; Jonathan P. Benskin^c ; Nik Veldhoen^b ; Bharat Chandramouli^a ; Heather Butler^a ; Caren C. Helbing^b ; John R. Cosgrove^a
• 关键词：Metabolomics ; Transcriptomics ; Systems biology ; Zebrafish ; Sublethal exposure ; Alternative animal model
• 刊名：Aquatic Toxicology
• 出版年：2017
• 出版时间：January 2017
• 年：2017
• 卷：182
• 期：Complete
• 页码：102-112
• 全文大小：2241 K
• 卷排序：182

文摘

A multi-omics approach was used to examine the impact of low-dose xenobiotics. Metabolomics and transcriptomics each offer unique molecular-level information. In combination, additional insights on potential impacts were revealed. Derived biological effects align with known mode-of-actions of the xenobiotics.