Vitamin D 25-hydroxylase - Four decades of searching, are we there yet?

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• 作者：Jinge Zhu ; Hector F. DeLuca ; ^{deluca@biochem.wisc.edu}
• 关键词：Cytochrome P450 enzymes ; CYP27A1 ; CYP2R1 ; CYP2J2/3 ; CYP3A4 ; CYP2D25 ; CYP2C11
• 刊名：Archives of Biochemistry and Biophysics
• 出版年：2012
• 出版时间：1 July, 2012
• 年：2012
• 卷：523
• 期：1
• 页码：30-36
• 全文大小：588 K

文摘

Bioactivation of vitamin D₃ involves 25-hydroxylation and subsequent 1¦Á-hydroxylation to produce 1¦Á,25-dihydroxyvitamin D₃ [1,25(OH)₂D₃], the active hormone. Six cytochrome P450 enzymes (CYP27A1, CYP2R1, CYP2J2/3, CYP3A4, CYP2D25 and CYP2C11) catalyzing the initial 25-hydroxylation step are reviewed, and their physiological relevance as vitamin D 25-hydroxylases in vivo is discussed.