Individual progression of carotid intima media thickness as a surrogate for vascular risk (PROG-IMT): Rationale and design of a meta-analysis project
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- 作者：Matthias W. Lorenz ; Horst Bickel ; Michiel L. Bots ; Monique M.B. Breteler ; Alberico L. Catapano ; Moise Desvarieux ; Bo Hedblad ; Bernhard Iglseder ; Stein Harald Johnsen ; Michal Juraska ; Stefan Kiechl ; El
- 刊名：American Heart Journal
- 出版年：2010
- 出版时间：May 2010
- 年：2010
- 卷：159
- 期：5
- 页码：730-736.e2
- 全文大小：460 K
文摘
Carotid intima media thickness (IMT) progression is increasingly used as a surrogate for vascular risk. This use is supported by data from a few clinical trials investigating statins, but established criteria of surrogacy are only partially fulfilled. To provide a valid basis for the use of IMT progression as a study end point, we are performing a 3-step meta-analysis project based on individual participant data.
Objectives of the 3 successive stages are to investigate (1) whether IMT progression prospectively predicts myocardial infarction, stroke, or death in population-based samples; (2) whether it does so in prevalent disease cohorts; and (3) whether interventions affecting IMT progression predict a therapeutic effect on clinical end points.
Recruitment strategies, inclusion criteria, and estimates of the expected numbers of eligible studies are presented along with a detailed analysis plan.