Chondroprotective effects of palmatine on osteoarthritis in vivo and in vitro: A possible mechanism of inhibiting the Wnt/β-catenin and Hedgehog signaling pathways
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- 作者：Xindie Zhoua ; b ; xindiezhou@yahoo.com" class="auth_mail" title="E-mail the corresponding author ; Xiaolong Linc ; Yan Xiongb ; Lifeng Jiangb ; Weijun Lib ; Jin Lib ; Lidong Wub ; ldwu@yahoo.com" class="auth_mail" title="E-mail the corresponding author
- 关键词：Osteoarthritis ; Palmatine ; Wnt signaling pathway ; Hedgehog signaling pathway ; Interleukin-1β ; Matrix metalloproteinase
- 刊名：International Immunopharmacology
- 出版年：2016
- 出版时间：May 2016
- 年：2016
- 卷：34
- 期：Complete
- 页码：129-138
- 全文大小：1785 K
文摘
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Pal inhibited inflammation in chondrocyte via Wnt/β-catenin and Hedgehog signaling pathways.
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Pal treatment attenuated the arthritis and inflammation in a rabbit osteoarthritis model.
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Pal inhibited Wnt/β-catenin and Hedgehog signaling pathways activation.
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Pal inhibited IL-1β-induced MMPs productions.