LRIG inhibitors of growth factor signalling – double-edged swords in human cancer?

详细信息    查看全文

• 作者：Hå ; kan Hedman ; Roger Henriksson
• 关键词：LRIG ; EGFR ; ErbB ; Tumour suppressor ; Receptor tyrosine kinase
• 刊名：European Journal of Cancer
• 出版年：2007
• 出版时间：March 2007
• 年：2007
• 卷：43
• 期：4
• 页码：676-682
• 全文大小：685 K

文摘

The leucine-rich repeats and immunoglobulin-like domains (LRIG) proteins are newly discovered negative regulators of growth factor signalling and proposed tumour suppressors. They antagonise signalling by interacting with growth factor receptors and by enhancing their ubiquitylation and degradation. Data on the expression of LRIG in human cancer have recently begun to accumulate; however, not all data appear consistent with the notion that the LRIG proteins always function as tumour suppressors. In the present review, we argue that the LRIG proteins could be double-edged swords, promoting or suppressing human cancer depending on cellular context.