Absence of human bocavirus from deceased fetuses and their mothers

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• 作者：Anita Riipinen ; Elina Vä ; isä ; nen ; Anne Lahtinen ; Riitta Karikoski ; Mika Nuutila ; Heljä ; -Marja Surcel ; Helena Taskinen ; Klaus Hedman ; Maria Sö ; derlund-Venermo
• 刊名：Journal of Clinical Virology
• 出版年：2010
• 出版时间：February 2010
• 年：2010
• 卷：47
• 期：2
• 页码：186-188
• 全文大小：128 K

文摘

Background

The human bocavirus (HBoV), a newly discovered parvovirus, is closely related to the bovine parvovirus and the canine minute virus, which are known to cause adverse pregnancy outcomes. Another human parvovirus, B19, can lead to fetal hydrops, miscarriage and intrauterine fetal death (IUFD).

Objectives

To determine the prevalence of HBoV DNA in aborted fetuses and IUFDs. The HBoV serology of the mothers was also studied.

Study design

We retrospectively studied all available fetuses (N = 535) autopsied during 7/1992–12/1995, and 1/2003–12/2005 in Helsinki, Finland. All available formalin-fixed paraffin-embedded fetal tissues – placenta, heart and liver – of 120 miscarriages, 169 IUFDs, and 246 induced abortions were studied by quantitative PCR. We also measured the HBoV IgM and IgG antibodies in the corresponding maternal sera (N = 462) mostly of the first trimester. The IgM-positive sera underwent HBoV PCR.

Results

None of the fetal tissues harbored HBoV DNA. A total of 97 % (448/462) of the mothers were positive for IgG antibodies to HBoV, while only 0.9 % (4/462) exhibited HBoV-specific IgM antibodies without viremia or respiratory symptoms. One IgM-positive mother had an unexplained fetal loss.

Conclusions

We did not find HBoV DNA in any of the deceased fetuses. Almost all pregnant women were HBoV-IgG positive.