Retrospectively analyzed, prospectively obtained database.
Bundang CHA General Hospital in South Korea.
Fifty-nine SAEs (<20 wk of gestational age) with normal chromosomal integrity.
None.
Genotype frequency of MTHFR, TSER polymorphisms, and methylation status of p16INK4A and hMLH1 genes in SAEs with normal chromosomal integrity.
The distribution of the MTHFR 677C>T polymorphism differed significantly between SAEs with normal chromosomal integrity and the two control groups. Also, the frequency of combined MTHFR 677 and TSER genotypes was significantly different between the aborted embryos and the adult control group. However, the MTHFR 677C>T and 1298A>C and TSER polymorphisms were not associated with the methylation status of p16INK4A and hMLH1 genes in SAEs with normal chromosomal integrity.
Association between the MTHFR 677C>T polymorphism and the risk of SAEs with normal chromosomal integrity in the Korean population.