RNA-binding protein HuD reduces triglyceride production in pancreatic β cells by enhancing the expression of insulin-induced gene 1
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- 作者：Chongtae Kima ; Heejin Leea ; Hoin Kanga ; Jung Jae Shinb ; Hyosun Taka ; Wook Kimb ; Myriam Gorospec ; Eun Kyung Leea ; d ; leeek@catholic.ac.kr" class="auth_mail" title="E-mail the corresponding author
- 关键词：RNA-binding protein ; HuD ; Triglyceride ; INSIG1 ; SREBP1c
- 刊名：Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms
- 出版年：2016
- 出版时间：April 2016
- 年：2016
- 卷：1859
- 期：4
- 页码：675-685
- 全文大小：2240 K
文摘
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RNA binding protein HuD regulates intracellular triglyceride accumulation.
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HuD promotes INSIG expression by binding its 3ʹUTR.
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Down-regulation of HuD enhances nuclear translocation of SREBP1c.
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HuD and INSIG decrease in db/db mice.