Dopamine modulates attentional control of auditory perception: DARPP-32 (PPP1R1B) genotype effects on behavior and cortical evoked potentials

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• 作者：Shu-Chen Li ; Susanne Passow ; Wilfried Nietfeld ; Julia Schr?der ; Lars Bertram ; Hauke R. Heekeren ; Ulman Lindenberger
• 关键词：Attention ; Selective attention ; Conflict monitoring ; Auditory processing ; Dopamine ; Evoked potentials ; DARPP-32 ; PPP1R1B
• 刊名：Neuropsychologia
• 出版年：2013
• 出版时间：July, 2013
• 年：2013
• 卷：51
• 期：8
• 页码：1649-1661
• 全文大小：2801 K

文摘

Using a specific variant of the dichotic listening paradigm, we studied the influence of dopamine on attentional modulation of auditory perception by assessing effects of allelic variation of a single-nucleotide polymorphism (SNP) rs907094 in the DARPP-32 gene (dopamine and adenosine 3¡ä, 5¡ä-monophosphate-regulated phosphoprotein 32 kilodations; also known as PPP1R1B) on behavior and cortical evoked potentials. A frequent DARPP-32 haplotype that includes the A allele of this SNP is associated with higher mRNA expression of DARPP-32 protein isoforms, striatal dopamine receptor function, and frontal-striatal connectivity. As we hypothesized, behaviorally the A homozygotes were more flexible in selectively attending to auditory inputs than any G carriers. Moreover, this genotype also affected auditory evoked cortical potentials that reflect early sensory and late attentional processes. Specifically, analyses of event-related potentials (ERPs) revealed that amplitudes of an early component of sensory selection (N1) and a late component (N450) reflecting attentional deployment for conflict resolution were larger in A homozygotes than in any G carriers. Taken together, our data lend support for dopamine's role in modulating auditory attention both during the early sensory selection and late conflict resolution stages.