Delayed improvement of insulin secretion after autologous islet transplantation in partially pancreatectomized patients
详细信息 查看全文
- 作者：Hye Seung Jung ; Seong-Ho Choi ; Sung-Joo Kim ; Dong-Wook Choi ; Jin-Seok Heo ; Kyu Taek Lee ; Jong Kyun Lee ; Kee-Taek Jang ; Byung-Wan Lee ; Jae-Hwan Jee ; Jung-Hyun Noh ; In Kyung Jeong ; Tae-Young Yang ; Seung-Hoon Oh ; You-Ran Ahn ; Young-Seok Kim ; Heesung No ; Moon-Kyu Lee ; Kwang-Won Kim
- 刊名：Metabolism
- 出版年：2009
- 出版时间：November 2009
- 年：2009
- 卷：58
- 期：11
- 页码：1629-1635
- 全文大小：313 K
文摘
The purpose of this study was to evaluate the effects of autologous islet transplantation (ITx) on glucose homeostasis and insulin secretory function after partial pancreatectomy (Px). Fourteen nondiabetic patients who underwent distal Px and autologous ITx for benign pancreatic tumors were enrolled in the study (Px + ITx group). Fourteen normal glucose-tolerant controls and 6 Px without ITx controls were recruited, and all groups were followed over a 24-month period. They performed the 75-g oral glucose tolerance test and the 1-mg glucagon stimulation test. Hemoglobin A1c was measured, and indices of insulin secretion were calculated. In the Px + ITx group, insulin secretion increased after a nadir at 6 months. Glucose tolerance, which had been abruptly impaired immediately after Px, recovered until 6 months and stabilized thereafter. As a result, differences in glucose intolerance emerged between the subjects in the Px group and those in the Px + ITx group at 24 months after Px. Characteristic variables in the better insulin secretory subjects in the Px + ITx group included younger age, less extensive pancreas resection, and a greater number of total islets. In summary, delayed amelioration of glucose intolerance was induced by autologous ITx after partial Px, even with a small number of islets.