SARI, a novel target gene of glucocorticoid receptor, plays an important role in dexamethasone-mediated killing of B lymphoma cells
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- 作者：Yinghui Huanga ; b ; 1 ; Jie Zhouc ; 1 ; Yan Huangd ; 1 ; Jintao Hee ; Yuting Wanga ; Chaohui Yanga ; Dongbo Liua ; Li Zhanga ; lizhang2013@aliyun.com" class="auth_mail" title="E-mail the corresponding author ; Fengtian Hea ; hefengtian06@aliyun.com" class="auth_mail" title="E-mail the corresponding author
- 关键词：Glucocorticoid receptor ; SARI ; Dexamethasone ; Lymphoma ; Gene regulation
- 刊名：Cancer Letters
- 出版年：2016
- 出版时间：1 April 2016
- 年：2016
- 卷：373
- 期：1
- 页码：57-66
- 全文大小：3477 K
文摘
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Dexamethasone (Dex)-treated B lymphoma tissues have a higher level of SARI.
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Dex represses the growth of B lymphoma cells in vitro and in vivo.
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Dex upregulates SARI expression via activating glucocorticoid receptor (GR).
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GR directly binds to the ER9 element (−178 to −158) in SARI promoter region.
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SARI induction plays an important role in Dex's killing effect on B lymphoma cells.