HCC cells with high levels of Bcl-2 are resistant to ABT-737 via activation of the ROS-JNK-autophagy pathway
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- 作者：Zhenhong Nia ; 1 ; Bin Wanga ; 1 ; Xufang Daib ; Wen Dinga ; Ting Yanga ; Xinzhe Lia ; Seth Lewinc ; Liang Xuc ; Jiqin Liana ; lianjiqin@sina.com" class="auth_mail ; Fengtian Hea ; hefengtian06@aliyun.com" class="auth_mail
- 关键词：HCC ; hepatocellular carcinoma ; Bcl-2 ; B-cell lymphoma-2 ; LC3 ; microtubule-associated protein 1 light chain 3 ; JNK ; c-Jun N-terminal kinase ; siRNA ; small interfering RNA ; CQ ; chloroquine ; GSH ; glutathione ; NAC ; N-acetyl-l-cysteine ; ROS ; reactive oxygen species ; GAPDH ; glyceraldehyde phosphate dehydrogenase
- 刊名：Free Radical Biology and Medicine
- 出版年：May 2014
- 年：2014
- 卷：70
- 期：Complete
- 页码：194-203
- 全文大小：2915 K
文摘
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HCC cells with high levels of Bcl-2 are dramatically resistant to ABT-737.
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ABT-737 triggers the ROS–JNK–autophagy pathway in HCC cells with high Bcl-2.
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ABT-737 activates the ROS–JNK–apoptosis pathway in HCC cells with low Bcl-2.