Decreased fetal pre-adipocyte factor-1 in pregnancies complicated by gestational diabetes mellitus

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• 作者：Jie Li ; Qiuyuan Zhu ; Hanzhi Wang ; Cong Han ; Qunyan Zhou ; Hefeng Huang ; Minyue Dong ; ^{mydong.cn@hotmail.com" class="auth_mail}
• 关键词：Gestational diabetes ; Preadipocyte factor-1 ; Fetus ; Metabolic diseases
• 刊名：Clinica Chimica Acta
• 出版年：20 April, 2014
• 年：2014
• 卷：431
• 期：Complete
• 页码：93-95
• 全文大小：273 K

文摘

Background

Serum pre-adipocyte factor-1 (pref-1) is an inhibitor of adipocyte differentiation that increases in small for gestational age fetuses. It plays a role in adipose metabolism and is associated with an increased risk of metabolic diseases in adulthood. We hypothesized that preadipocyte factor-1 (pref-1) concentration is altered in fetuses born to women with gestational diabetes mellitus (GDM).

Methods

Umbilical cord blood pref-1 concentrations were determined by enzyme-linked immunosorbant assay in 37 fetuses from pregnancies complicated by GDM and 45 fetuses from normal pregnancies.

Results

Serum pref-1 concentrations were significantly lower in fetuses of women with GDM compared to normal pregnancies (16.12 卤 6.48 vs. 22.09 卤 7.22 渭g/l, P = 0.001). Birth weight was significantly higher in GDM fetuses compared to normal pregnancies (3567 卤 544 vs. 3253 卤 370 g, P = 0.003).

Conclusions

Pregnancies complicated by GDM have decreased fetal pref-1 concentrations compared to normal pregnancies. These differences may be significant in terms of their later development of metabolic conditions.