Apoptosis Susceptibility Prolongs the Lack of Memory B Cells in Acute Leukemic Patients After Allogeneic Hematopoietic Stem Cell Transplantation
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- 作者：Angela Mensen1 ; Youngseong Oh1 ; Sonya C. Becker1 ; Philipp G. Hemmati2 ; Christian Jehn2 ; Jö ; rg Westermann2 ; Martin Szyska3 ; Henning Gö ; ldner2 ; Bernd Dö ; rken2 ; 4 ; Carmen Scheibenbogen1 ; 5 ; Renate Arnold2 ; Il-Kang Na1 ; 2 ; 3 ; il-kang.na@charite.de" class="auth_mail" title="E-mail the corresponding author
- 关键词：Allogeneic hematopoietic stem cell transplantation ; B cell intrinsic and germinal center defects ; Long-term memory B cell paucity
- 刊名：Biology of Blood and Marrow Transplantation
- 出版年：2015
- 出版时间：November 2015
- 年：2015
- 卷：21
- 期：11
- 页码：1895-1906
- 全文大小：3007 K
文摘
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The germinal center–dependent generation of memory B cells appears defective in allogeneic hematopoietic stem cell transplantation patients
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B cell survival, antigen presentation, and migration defects are potential contributors
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A sustained inflammatory milieu may support B cell apoptosis susceptibility
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There is a basis for investigation of defective memory B cell generation in murine hematopoietic stem cell transplantation models
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There may be a rationale for adoptive memory B cell transfer to improve B cell immunity in patients