ER-Stress-Induced Differentiation Sensitizes Colon Cancer Stem Cells to Chemotherapy
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- 作者：Mattheus C.B. Wielenga1 ; 4 ; Selcuk Colak2 ; 4 ; Jarom Heijmans1 ; Jooske F. van Lidth de Jeude1 ; Hans M. Rodermond2 ; James C. Paton3 ; Adrienne W. Paton3 ; Louis Vermeulen2 ; Jan Paul Medema2 ; 5 ; j.p.medema@amc.uva.nl" class="auth_mail" title="E-mail the corresponding author ; Gijs R. van den Brink1 ; 5 ; g.r.vandenbrink@amc.uva.nl" class="auth_mail" title="E-mail the corresponding author
- 刊名：Cell Reports
- 出版年：2015
- 出版时间：20 October 2015
- 年：2015
- 卷：13
- 期：3
- 页码：489-494
- 全文大小：1543 K
文摘
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Colon-CSCs are more resistant to chemotherapy than differentiated cancer cells
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Activation of the unfolded protein response causes differentiation of colon-CSCs
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UPR-induced differentiation enhances response to chemotherapy in vitro and in vivo