Comparison of the Modulatory Effects of Four Different Fast-Track Anesthetic Techniques on the Inflammatory Response to Cardiac Surgery With Cardiopulmonary Bypass

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• 作者：John Heijmans ; Erik Fransen ; Wim Buurman ; Jos Maessen ; Paul Roekaerts
• 关键词：inflammation mediators ; anesthesia ; intravenous ; alfentanil ; propofol ; remifentanil ; epidural ; cardiac surgical procedures ; cardiopulmonary bypass
• 刊名：Journal of Cardiothoracic and Vascular Anesthesia
• 出版年：2007
• 出版时间：August 2007
• 年：2007
• 卷：21
• 期：4
• 页码：512-518
• 全文大小：318 K

文摘

Angiotensin II (AngII) modulates the balance between matrix metalloproteinases (MMPs) and tissue inhibitors of MMPs (TIMPs), and AngII type 1 receptor (AT₁R) blockers (ARBs) limit left ventricular (LV) dysfunction and remodeling after acute ischemia-reperfusion (IR). Whether ARBs improve TIMP/MMP balance during IR has not been determined.

Methods and results

We measured hemodynamics, LV function, MMP-2 and MMP-9, and TIMP-3 and TIMP-4 in the ischemic zone (IZ) and nonischemic zone (NIZ) after in vivo IR (90 minutes anterior ischemia; 120 minutes reperfusion) in 28 dogs that were randomized to sham, IR controls, and IR plus the ARB valsartan. In controls, IR induced LV dysfunction, infarction, and IZ remodeling; increased MMP-9 and decreased TIMP-3 in the IZ compared with the NIZ (low TIMP-3/MMP-9 ratio); and did not change MMP-2 or TIMP-4. Compared with controls, valsartan (1) limited LV dysfunction, infarct size, and IZ remodeling; (2) increased MMP-2 and MMP-9 and TIMP-3 and -4 in the NIZ; and (3) increased TIMP-3 and the TIMP-3/MMP-9 ratio in the IZ, but did not change MMP-2 and TIMP-4.

Conclusion

Valsartan-induced cardioprotection after IR is associated with enhanced TIMP-3 expression and improved TIMP-3/MMP-9 balance in the in vivo dog model.