Flattening filter free technique in breath-hold treatments of left-sided breast cancer: The effect on beam-on time and dose distributions

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• 作者：Tuomas Koivum&auml ; ki^a ; ^{tuomas.koivumaki@kuh.fi" class="auth_mail" title="E-mail the corresponding author} ; Janne Heikkil&auml ; ^a ; Anssi V&auml ; &auml ; n&auml ; nen^a ; Kristiina Koskela^a ; Saara Sillanm&auml ; ki^b ; Jan Sepp&auml ; l&auml ; ^a
• 关键词：Flattening filter free ; Volumetric modulated arc therapy ; Deep-inspiration breath-hold ; Breast cancer
• 刊名：Radiotherapy and Oncology
• 出版年：2016
• 出版时间：January 2016
• 年：2016
• 卷：118
• 期：1
• 页码：194-198
• 全文大小：601 K

文摘

The use of flattening filter free (FFF) beams has potential to speed up deep-inspiration breath-hold treatments. In this study, the beam-on time and dose characteristics of left-sided breast treatment plans with FFF and flattened beams were evaluated.

Material and methods

Twelve plans were generated for 20 patients. The techniques utilized were volumetric modulated arc therapy with two limited tangential arcs (tVMAT) and tangential intensity modulated radiotherapy with dynamic (dIMRT) as well as step-and-shoot (FinF) dose delivery. Each technique was planned with FFF and flattened beams with 6 and 10 MV photons. All plans were irradiated and the beam-on times were measured. Dose characteristics of planning target volume (PTV) and organs at risk (OAR) were evaluated.

Results

The mean beam-on times were reduced by 18–39% using FFF. Mean PTV dose coverage was least reduced with tVMAT (0.6–0.8%) compared to dIMRT (4%) and FinF (5.6–9.1%), when FFF beams were used instead of flattened beams. Only small differences were observed in OAR doses between equivalent plans (FFF vs. flattened).

Conclusions

A significant reduction was observed in beam-on time when utilizing FFF beams with tVMAT, dIMRT and FinF. tVMAT was the only technique for which the use of FFF did not degrade the treatment plan dose distributions.