Human cytosolic sulphotransferases: genetics, characteristics, toxicological aspects
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- 作者：Glatt ; Hansruedi ; Boeing ; Heiner ; Engelke ; Christina E.H. ; Ma ; Lan ; Kuhlow ; Andreas ; Pabel ; Ulrike ; et. al.
- 关键词：Sulphotransferase ; SULT ; Endogenous and xenobiotic metabolism ; Genetic polymorphisms ; Bioactivation
- 刊名：Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis
- 出版年：2001
- 出版时间：October 1, 2001
- 年：2001
- 卷：482
- 期：1-2
- 页码：27-40
- 全文大小：115 K
文摘
Cytosolic sulphotransferases transfer the sulpho moiety from the cofactor 5′-phosphoadenosine-3′-phosphosulphate (PAPS) to nucleophilic groups of xenobiotics and small endogenous compounds (such as hormones and neurotransmitters). This reaction often leads to products that can be excreted readily. However, other sulpho conjugates are strong electrophiles and may covalently bind with DNA and proteins. All known cytosolic sulphotransferases are members of an enzyme/gene superfamily termed SULT. In humans, 10 SULT genes are known. One of these genes encodes two different enzyme forms due to the use of alternative first exons. Different SULT forms substantially differ in their substrate specificity and tissue distribution. Genetic polymorphisms have been described for three human SULTs. Several allelic variants differ in functional properties, including the activation of promutagens. Only initial results are available from the analysis of SULT allele frequencies in different population groups, e.g. subjects suffering from specific diseases and corresponding controls.