Maternal hypertensive disorders in pregnancy and self-reported cognitive impairment of the offspring 70 years later: the Helsinki Birth Cohort Study

详细信息    查看全文

• 作者：Soile Tuovinen ; MA^a ; Johan G. Eriksson ; MD ; DMSC^b ; ^d ; ^e ; ^f ; Eero Kajantie ; MD ; DMSC^c ; ^d ; Jari Lahti ; PhD^a ; Anu-Katriina Pesonen ; PhD^a ; Kati Heinonen ; PhD^a ; Clive Osmond ; PhD^g ; David J.P. Barker ; MD^g ; ^h ; Katri Rä ; ikkö ; nen ; PhD^a
• 关键词：adulthood ; cognitive impairment ; hypertensive disorders in pregnancy ; offspring
• 刊名：American Journal of Obstetrics and Gynecology
• 出版年：2013
• 出版时间：March, 2013
• 年：2013
• 卷：208
• 期：3
• 页码：200.e1-200.e9
• 全文大小：383 K

文摘

| Figures/TablesFigures/Tables | ReferencesReferences

Objective

We tested whether maternal hypertensive disorders during pregnancy predict self-reported cognitive impairment, which is one of the earliest behavioral markers of dementia, of the offspring 70 years later.

Study Design

We included 876 participants of the Helsinki Birth Cohort Study 1934-44 who were born after normotensive, preeclamptic, or hypertensive pregnancies that were defined by the use of the mother's blood pressure and urinary protein measurements at maternity clinics and birth hospitals. The participants completed a psychological questionnaire that included questions on cognitive failures and dysexecutive functioning at an average age of 69.3 ¡À 3.1 (SD) years.

Results

In comparison with the offspring who were born after normotensive pregnancies, the offspring who were born after preeclamptic pregnancies reported more frequent complaints of cognitive failures, distractibility, and false triggering. Further, among women we found maternal hypertension without proteinuria that was associated with more frequent complaints of cognitive failures, forgetfulness, and false triggering.

Conclusion

Hypertensive disorders during pregnancy are associated with more frequent subjective complaints of cognitive failures of the offspring in old age.