In Vivo Killing Capacity of Cytotoxic T Cells Is Limited and Involves Dynamic Interactions and T Cell Cooperativity
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- 作者：Stephan Halle1 ; halle.stephan@mh-hannover.de" class="auth_mail" title="E-mail the corresponding author ; Kirsten Anja Keyser2 ; Felix Rolf Stahl1 ; 10 ; Andreas Busche2 ; 11 ; Anja Marquardt2 ; 12 ; Xiang Zheng1 ; Melanie Galla3 ; Vigo Heissmeyer4 ; 5 ; Katrin Heller1 ; Jasmin Boelter1 ; Karen Wagner2 ; Yvonne Bischoff1 ; Rieke Martens1 ; Asolina Braun1 ; 13 ; Kathrin Werth1 ; Alexey Uvarovskii6 ; Harald Kempf6 ; Michael Meyer-Hermann6 ; 7 ; Ramon Arens8 ; Melanie Kremer9 ; Gerd Sutter9 ; Martin Messerle2 ; Reinhold Fö ; rster1 ; foerster.reinhold@mh-hannover.de" class="auth_mail" title="E-mail the corresponding author
- 刊名：Immunity
- 出版年：2016
- 出版时间：16 February 2016
- 年：2016
- 卷：44
- 期：2
- 页码：233-245
- 全文大小：3947 K
文摘
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Two-photon imaging indicates that CTLs kill 2–16 virus-infected cells per day
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CTLs form kinapses rather than stable synapses when killing virus-infected cells
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Some CTL contacts trigger long-lasting calcium fluxes in virus-infected cells
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CTLs can cooperate during killing of virus-infected cells