Discovery of antiviral molecules for dengue: In silico search and biological evaluation
详细信息 查看全文
- 作者：Maria Cabarcas-Montalvoa ; Wilson Maldonado-Rojasa ; Diana Montes-Grajalesa ; Angela Bertel-Sevillaa ; Irene Wagner-Dö ; blerb ; Helena Sztajerb ; Michael Reckb ; Maria Flechas-Alarconc ; Raquel Ocazionezc ; Jesus Olivero-Verbela ; joliverov@unicartagena.edu.co" class="auth_mail" title="E-mail the corresponding author
- 关键词：Dengue protease inhibitor ; NS2B/NS3 complex ; Molecular docking ; In vitro inhibition ; Inhibitory activity
- 刊名：European Journal of Medicinal Chemistry
- 出版年：2016
- 出版时间：3 March 2016
- 年：2016
- 卷：110
- 期：Complete
- 页码：87-97
- 全文大小：1571 K
文摘
- •
In silico-in vitro assays were performed to find Dengue virus protease inhibitors.
- •
Three molecules showed promising inhibitory activity against DENV2 protease.
- •
Bis(4hydroxy2oxo2Hchromen3yl) (2methoxyphenyl)methyl is an anti-dengue motif.