All metabolites could be detected in nearly all urine samples (N=599). Descriptive data analysis leads to mean concentrations of 5-OH-MEHP and 5-oxo-MEHP of 48 μg/l and 37 μg/l, respectively. The mean concentration of 7OH-MMeOP was 11 μg/l. MnBP, MiNP, MBzP showed mean levels of 96 μg/l, 94 μg/l, and 18 μg/l, respectively. The concentrations of the phthalate metabolites decreased with increasing age. Compared to German adults all children showed three to five fold higher urine concentrations than adults analysed in the same decade.
For some children the levels of the sum of 5OH-MEHP and 5oxo-MEHP in urine were higher than the German human biomonitoring value (HBM I) of 500 μg/l, which indicates that adverse health effects cannot be excluded for these subjects with sufficient certainty.
The mean concentration of BPA in urine was 2.7 μg/l. A rough calculation of the daily intakes on the basis of the measured concentrations in urine resulted in daily intakes two orders of magnitude lower than the current EFSA reference dose of 50 μg/kg bw/d.