Novel O-linked methylated glycan antigens decorate secreted immunodominant glycoproteins from the intestinal nematode Heligmosomoides polygyrus
详细信息 查看全文
- 作者：James P. Hewitsona ; 1 ; D. Linh Nguyenb ; Angela van Diepenb ; Cornelis H. Smitb ; Carolien A. Koelemanb ; Henry J. McSorleya ; Janice Murraya ; Rick M. Maizelsa ; 2 ; Cornelis H. Hokkeb ; 2 ; c.h.hokke@lumc.nl" class="auth_mail" title="E-mail the corresponding author
- 关键词：Nematode ; Heligmosomoides polygyrus ; Carbohydrate ; Mass spectrometry ; Excretory&ndash ; secretory product ; Antibody
- 刊名：International Journal for Parasitology
- 出版年：2016
- 出版时间：March 2016
- 年：2016
- 卷：46
- 期：3
- 页码：157-170
- 全文大小：1556 K
文摘
- •
Heligmosomoides polygyrus excretory–secretory (ES) proteins carry diverse N- and O-glycans, and many are O-methylated.
- •
A methylhexose containing O-glycan of abundant ES glycoproteins is immunodominant.
- •
This dominant glycan is not the immunomodulatory heat-stable ES component.