Synthesis, chemical stability and application of a thiohydroxamic acid linker (THA) for solid-phase organic synthesis

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• 作者：David M. Whitehead ; Philip A. Helliwell ; Stephen C. McKeown ; Anne Routledge
• 关键词：Radical reaction ; Solid-phase synthesis ; Thiohydroxamic acid
• 刊名：Reactive and Functional Polymers
• 出版年：2009
• 出版时间：December 2009
• 年：2009
• 卷：69
• 期：12
• 页码：884-890
• 全文大小：394 K

文摘

The synthesis and chemical compatibility of a ‘traceless’ thiohydroxamic acid (THA) linker is reported. The linker is shown to be stable to visible light and heat. This paper also describes preliminary work in the application of the THA linker to act as a polymer-supported source of radicals.