Epigenetic regulation of BDNF in the learned helplessness-induced animal model of depression
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- 作者：Chun-Lin Su1 ; Chun-Wei Su1 ; Ya-Hsin Hsiao ; Po-Wu Gean ; powu@mail.ncku.edu.tw" class="auth_mail" title="E-mail the corresponding author
- 关键词：Learned helplessness ; Brain derived neurotrophic factor ; Depression ; Epigenetics
- 刊名：Journal of Psychiatric Research
- 出版年：2016
- 出版时间：May 2016
- 年：2016
- 卷：76
- 期：Complete
- 页码：101-110
- 全文大小：1429 K
文摘
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Protein and mRNA levels of hippocampal BDNF was significantly lower in learned helplessness (LH) mice.
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Chronic imipramine or HDACi treatment could ameliorate depressive behavior and rescue decreased BDNF expression in LH mice.
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HDAC5 binding to promoter of Bdnf exon IV was significantly higher in LH than those of LH-R and control mice.
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Knockdown of HDAC5 expression prevented LH-induced depressive behaviors.
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These results suggest epigenetic regulation of BDNF plays an important role in the LH-induced depression.