Stress-based animal models of depression: Do we actually know what we are doing?
详细信息 查看全文
- 作者：Xin Yina ; Xin.Yin@utas.edu.au" class="auth_mail" title="E-mail the corresponding author ; Nuri Guvena ; Nikolas Dietisa ; b
- 关键词：MDD ; major depressive disorder ; WHO ; The World Health Organization ; SSRIs ; selective serotonin reuptake inhibitors ; SNRIs ; serotonin&ndash ; norepinephrine reuptake inhibitors ; MAOIs ; monoamine oxidase inhibitors ; TCAs ; tricyclic antidepressants ; FST ; forced swimming test ; TST ; tail suspension test ; LH ; learned helplessness ; HPA ; hypothalamic-pituitary-adrenal ; CMS ; chronic mild stress ; NS ; non-shock ; IS ; inescapable shock ; ES ; escapable shock ; SIA ; stress-induced analgesia
- 刊名：Brain Research
- 出版年：2016
- 出版时间：1 December 2016
- 年：2016
- 卷：1652
- 期：Complete
- 页码：30-42
- 全文大小：545 K
文摘
- •
Well characterized animal models are essential to develop new anti-depressants.
- •
Pre-clinical models do not recapitulate all aspects of the human diseases.
- •
To understand pros and cons of animal models is a key to interpret observed results.
- •
Forced swimming test has low validity and chronic mild stress is poorly duplicable.
- •
Learned helplessness paradigm is highly valid and useful to test antidepressants.