Efficacy of cocktail phage therapy in treating Vibrio cholerae infection in?rabbit model

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• 作者：Abhishek Jaiswal ; Hemanta Koley ; Amit Ghosh ; Anup Palit ; Banwarilal Sarkar ; ^{bl_sarkar@hotmail.com}
• 关键词：Vibrio cholerae ; Vibriophage ; Phage cocktail ; Lytic ; Oral administration
• 刊名：Microbes and Infection
• 出版年：2013
• 出版时间：February, 2013
• 年：2013
• 卷：15
• 期：2
• 页码：152-156
• 全文大小：340 K

文摘

Ability of a cocktail of five lytic vibriophages to combatting Vibrio cholerae O1 infection in rabbit model was examined. In one group, rabbits were administered 1?¡Á?10⁸ plaque forming unit of phage cocktail 6 and 12?h prior to the administration of V. cholerae O1, while in the other group, same procedure was applied 6 and 12?h post infection. It was observed that oral administration of the phage cocktail after oral bacterial challenge lowered the shedding of bacteria significantly (p?<?0.01). In contrast phage treatment prior to bacterial challenge had no such effect (p?>?0.05). Results suggest that oral administration of phage subsequent to V. cholerae challenge could provide a possible means of combatting V. cholerae infection.