Alterations in the bone marrow microenvironment may elicit defective hematopoiesis: a comparison of aplastic anemia, chronic myeloid leukemia, and normal bone marrow
Decreased T and B lymphopoiesis was demonstrated in both aplastic anemia (AA) and chronic myeloid leukemia (CML). Natural killer cells were observed in AA, but were absent in CML and control. There were significant differences between of AA and CML stromal cell components. Alteration of the osteoblasts or sinusoidal endothelium could modify hematopoietic stem cell levels. Changes in the bone marrow microenvironment could lead to AA or CML.