Aplastic Anemia and MDS International Foundation (AAMDSIF): Bone marrow failure disease scientific symposium 2016

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• 作者：Amer M. Zeidan ; ^{amer.zeidan@yale.edu}
• 关键词：BMFS ; bone marrow failure syndromes ; HSC ; hematopoietic stem cell ; BM ; bone marrow ; AML ; acute myelogenous leukemia ; MDS ; myelodysplastic syndromes ; LSC ; leukemia stem cell ; CHIP ; clonal hematopoiesis of indeterminate potential ; MDSCs ; myeloid derived suppressor cells ; LR ; lower risk ; CHIP ; clonal hematopoiesis of indeterminate potential ; TGF ; transforming growth factor ; HMA ; hypomethylating agent ; SCT ; stem cell transplantation ; RBC ; red blood cell ; HMA ; hypomethylating agent ; RBC ; red blood ce
• 刊名：Leukemia Research
• 出版年：2017
• 出版时间：February 2017
• 年：2017
• 卷：53
• 期：Complete
• 页码：8-12
• 全文大小：314 K
• 卷排序：53

文摘

Patients with acquired and inherited bone marrow failure syndromes (BMFS) have ineffective hematopoiesis due to impairments of the hematopoietic stem cell compartment. Common manifestations of BMFS include varying degrees of peripheral blood cytopenias and, sometimes, progression to acute myelogenous leukemia. Research efforts have been made all over the world to improve understanding of the pathogenesis of these diseases and their clinical implications. The Aplastic Anemia and MDS International Foundation (AAMDSIF) is an independent nonprofit organization whose mission is to help patients and family members cope with BMFS. Here, we summarize recent scientific discoveries in several BMFS that were presented at the fifth International Bone Marrow Failure Disease Scientific Symposium 2016 that AAMDSIF sponsored on March 17–18, 2016, in Rockville, Maryland.