Mobilization of hematopoietic stem cells with highest self-renewal by G-CSF precedes clonogenic cell mobilization peak
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- 作者：Ingrid G. Winklera ; Eliza Wiercinskab ; Valerie Barbiera ; Bianca Nowlana ; Halvard Bonigb ; c ; d ; Jean-Pierre Levesquea ; e ; jp.levesque@mater.uq.edu.au" class="auth_mail" title="E-mail the corresponding author
- 刊名：Experimental Hematology
- 出版年：2016
- 出版时间：April 2016
- 年：2016
- 卷：44
- 期：4
- 页码：303-314.e1
- 全文大小：2730 K
文摘
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After 2 days of administration of granulocyte colony-stimulating factor, mouse blood contains high levels of serially reconstituting hematopoietic stem cells.
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In mice, mobilization of serially reconstituting hematopoietic stem cells precedes that of clonogenic progenitors.
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In half of healthy volunteers tested, after 2 days of administration of granulocyte colony-stimulating factor, mobilized CD34+ cells are enriched in CD34+CD38− primitive progenitors.