BMP ligand-receptor interactions contribute to experimental tracheoesophageal fistula

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• 作者：Spilde ; Troy ; Crowley ; Amanda ; Mehta ; Sheilendra ; Ostlie ; Daniel ; Prasadan ; Krishna ; Hembree ; Mark ; et. al.
• 刊名：Journal of the American College of Surgeons
• 出版年：2004
• 出版时间：September, 2004
• 年：2004
• 卷：199
• 期：3
• 页码：30
• 全文大小：51.8 K

文摘

Introduction: The mechanism of formation of esophageal atresia with tracheoesophageal fistula (EA/TEF) remains unclear. Previously, we demonstrated that the fistula tract develops from a trifurcation of the embryonic lung bud. The fistula tract then grows caudally without branching, unlike the bronchi, which branch normally. Bone Morphogenetic Protein (BMP) signaling is critical to lung branching. We hypothesized that defects in BMP signaling may be causative in EA/TEF.