Placenta villous vessels in hydrops fetalis were assessed by computer morphometry.
Hb Bart hydrops fetalis cases were used as a model for severe fetal hypoxia.
Vessels in Hb Bart cases show a greater number, perimeter, and branching pattern.
These changes reflect hypoxia at pre-placental, placental and post-placental levels.
Standardized morphometry allows studies on placenta vascular lesions to be compared.