The metabolites of glutamine prevent hydroxyl radical-induced apoptosis through inhibiting mitochondria and calcium ion involved pathways in fish erythrocytes
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- 作者：Huatao Lia ; e ; Weidan Jianga ; b ; c ; Yang Liua ; b ; c ; Jun Jianga ; b ; c ; Yongan Zhangd ; Pei Wua ; b ; c ; Juan Zhaoa ; b ; c ; Xudong Duana ; b ; c ; Xiaoqiu Zhoua ; b ; c ; xqzhouqq@tom.com" class="auth_mail" title="E-mail the corresponding author ; zhouxq@sicau.edu.cn" class="auth_mail" title="E-mail the corresponding author ; Lin Fenga ; b ; c ; fenglin@sicau.edu.cn" class="auth_mail" title="E-mail the corresponding author
- 关键词：Cit ; citrulline ; CAD ; caspase-activated DNase ; PS ; phosphatidylserine ; ROS ; reactive oxygen species ; PUFAs ; polyunsaturated fatty acids ; EGTA ; ethylene glycol tetraacetic acid ; PI ; propidium iodide ; DCFH-DA ; 2&prime ; 7&prime ; -dichlorofluorescin diacetate ; PCS ; physiological carp saline ; Hb ; hemoglobin ; AHR ; anti-hydroxyl radical ; Ala10Pro4Cit1 ; the combination of Ala ; Pro and Cit ; TUNEL ; the terminal deoxyribonucleotide transferase (TdT)-mediated dUTP nick end labeling ; LMWPs ; the low-molecular-
- 刊名：Free Radical Biology and Medicine
- 出版年：2016
- 出版时间：March 2016
- 年：2016
- 卷：92
- 期：Complete
- 页码：126-140
- 全文大小：2164 K
文摘
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There are two distinct apoptosis pathways in fish erythrocytes.
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Fish erythrocytes may be used as a cellular model in mammal cells.
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Gln’s metabolites protect erythrocytes against apoptosis and oxidative stress.
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The anti-oxidative and apoptotic effects of Gln are depended on its metabolites.