Crystallographic characterization of the nitric oxide derivative of R-state human hemoglobin
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- 作者：Jun Yia ; b ; ; Alexei S. Soaresc ; George B. Richter-Addoa ; grichteraddo@ou.edu" class="auth_mail
- 关键词：Hemoglobin ; Iron ; Nitric oxide ; X-ray ; Nitrosyl
- 刊名：Nitric Oxide
- 出版年：30 May 2014
- 年：2014
- 卷：39
- 期：Complete
- 页码：46-50
- 全文大小：636 K
文摘
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The crystal structure of the NO derivative of R-state human Hb has been determined.
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The Fe centers in both 伪 and 尾 subunits are six-coordinate.
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Structural differences in the FeNO moieties suggest a stronger interaction of NO with Fe in the 伪 subunit.
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The hydrogen bonding patterns suggest a greater retention of NO in the 伪 distal pocket.