Sustainable efficient way for opioid peptide LVV-h7 preparation from enzymatic proteolysis in a microfluidic-based reaction-extraction process with solvent recycling
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- 作者：Adil Elaglia ; b ; Kalim Belhacenea ; b ; Pascal Dhulstera ; Renato Froidevauxa ; renato.froidevaux@univ-lille1.fr" class="auth_mail" title="E-mail the corresponding author
- 关键词：Enzymatic hydrolysis ; Bioactive peptide ; Liquid&ndash ; liquid extraction ; Microfluidics ; Solvent recycling
- 刊名：Journal of Chromatography B, Analytical Technologies in the Biomedical and Life Sciences
- 出版年：2016
- 出版时间：1 May 2016
- 年：2016
- 卷：1020
- 期：Complete
- 页码：24-28
- 全文大小：686 K
文摘
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An original strategy of bioactive peptide preparation by a liquid–liquid microextraction is proposed.
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The role of both reaction and extraction during protein hydrolysis by enzyme and solvent extraction is investigated.
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The enzyme reaction following by selective hemorphin extraction and solvent recycling are analyzed.