Can we find a possible structural explanation for antibody-dependent enhancement of dengue virus infection resulting in hemorrhagic fever?

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• 作者：Cecilia P. Mikita^a ; ^{cecilia.p.mikita.civ@mail.mil" class="auth_mail" title="E-mail the corresponding author} ; Eduardo A. Padlan^b
• 刊名：Medical Hypotheses
• 出版年：2016
• 出版时间：March 2016
• 年：2016
• 卷：88
• 期：Complete
• 页码：49-52
• 全文大小：481 K

文摘

Dengue virus infection is one of the most prevalent mosquito-borne illnesses worldwide, affecting as many as 400 million persons annually. Most people experience a self-limited viral illness, but some experience life-threatening disease. Subsequent infection with other dengue virus serotypes increases the risk of development of severe dengue disease with plasma leakage with or without hemorrhage and end organ impairment. Antibody-dependent enhancement of dengue virus infection has been implicated in the development of severe dengue disease, previously referred to as dengue hemorrhagic fever and dengue shock syndrome. We propose a structural explanation for the role of non-neutralizing antibodies in the development of antibody-dependent enhancement of dengue virus infection via complement fixation or binding to Fcγ receptors facilitating entry into target cells.