Gene expression profiling in anti-CD11d mAb-treated spinal cord-injured rats
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- 作者：Paul Gris ; Allyson Tighe ; Sakina Thawer ; Andrew Hemphill ; Mark Oatway ; Lynne Weaver ; Gregory A. Dekaban ; Arthur Brown
- 关键词：Spinal cord injury ; Genomics ; Microarray ; Gene expression profiling ; Anti-inflammatory ; CSPGs
- 刊名：Journal of Neuroimmunology
- 出版年：2009
- 出版时间：30 April 2009
- 年：2009
- 卷：209
- 期：1-2
- 页码：104-113
- 全文大小：1388 K
文摘
Acute administration of a mononclonal antibody (mAb) raised against the CD11d subunit of the leukocyte CD11d/CD18 integrin after spinal cord injury (SCI) in the rat greatly improves neurological outcomes. We have profiled gene expression in anti-CD11d and isotyped-matched control mAb-treated rats after SCI. Microarray analysis demonstrated reduced expression of pro-inflammatory cytokines and increased expression of inflammatory mediators that promote wound healing and the expression of scar proteins predicted to improve nerve growth. These changes in gene expression may reflect changes in the types of macrophages that populate the lesions in anti-CD11d mAb-treated rats.