A comparative study to screen dementia and APOE genotypes in an ageing East African population

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• 作者：Chien-Hsiun Chen ; Toshiki Mizuno ; Robert Elston ; Monica M. Kariuki ; Kathleen Hall ; Fred Unverzagt ; Hugh Hendrie ; Samuel Gatere ; Paul Kioy ; Nilesh B. Patel ; Robert P. Friedl ; Raj N. Kalaria
• 关键词：Africa ; Alzheimer's disease ; Apolipoprotein E ; Cognitive impairment ; Dementia ; Kenya ; Neuropsychology
• 刊名：Neurobiology of Aging
• 出版年：2010
• 出版时间：May 2010
• 年：2010
• 卷：31
• 期：5
• 页码：732-740
• 全文大小：283 K

文摘

Previous studies have established cross-cultural methods to screen for ageing- related dementia and susceptibility genes, in particular Alzheimer's disease (AD) among the Canadian Cree, African Americans and Yoruba in Nigeria. We determined whether the Community Screening Interview for Dementia (CSID), translated into Kikuyu, a major language of Kenya, could be used to evaluate dementia of the Alzheimer type. Using two sets of coefficients of cognitive and informant scores, two discriminant function (DF) scores were calculated for each of 100 elderly (>65 years) Nyeri Kenyans. When the cut-off points were selected for 100 % sensitivities, the specificities of the DF scores were remarkably similar (93.75 % ) in the Kenyan sample. We propose the adapted CSID can be utilised to detect dementia among East Africans. We also show that apolipoprotein E 4 allele frequencies were high (30 % ) and not different between normal subjects and those with probable AD. There was no evidence to suggest years of education or vascular factors were associated with dementia status.