The interaction of broadband intense pulsed light (IPL) and skin during a multi-pulse application

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• 作者：Jeffrey Myhill ; Wolfgang Bä ; umler ; Leah Hennings ; Edward D. Bearden ; Lisa M. Buckmiller ; Gal Shafirstein
• 关键词：Intense pulsed light (IPL) ; Multi-pulse ; Port-wine stain ; Vascular malformations
• 刊名：Medical Laser Application
• 出版年：2008
• 出版时间：15 May 2008
• 年：2008
• 卷：23
• 期：2
• 页码：71-78
• 全文大小：1181 K

文摘

Intense pulsed light (IPL) systems are being presented as an alternative to conventional laser therapy for the treatment of vascular lesions. Broad spectral emission, radiant exposure, and pulse time are the key parameters for any IPL system used in clinical practice. Herein, we present the concept of using multi-pulse delivery to improve the vascular damage caused by IPL light.

The result of our animal study shows an increase in tissue temperature that depends on the number of applied IPL pulses. However, this temperature increase is not a function of heat accumulation. In our study, the peak temperature after each pulse decreased to baseline prior to each successive pulse. A temperature increase of 25 °C is possible with five consecutive 30 ms pulses of 18 J/cm² with a 9 s time interval. We show that in healthy, human-like skin, multi-pulse IPL can achieve selective vascular and perivascular damage with little thermal injury to the epidermis and dermis after proper cooling during treatment. The thermal damage of the vessels could have been enhanced due to an increased blood perfusion that is caused by the multiple pulses. The IPL system provides the clinician a treatment modality with more adjustable parameters to improve the clinical response of various skin types and vascular lesions. We theorize that port-wine stains should respond to multi-pulse IPL therapy in a similar fashion to our healthy, human skin model.