High-intensity focused ultrasound for potential treatment of polycystic ovary syndrome: toward a noninvasive surgery

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• 作者：Islam A. Shehata ; John R. Ballard ; Andrew J. Casper ; Leah J. Hennings ; Erik Cressman ; Emad S. Ebbini
• 关键词：Polycystic ovary syndrome (PCOS) ; high-intensity focused ultrasound (HIFU) ; dual-mode ultrasound arrays (DMUA) ; laparoscopic ovarian drilling (LOD) ; infertility
• 刊名：Fertility and Sterility
• 出版年：February, 2014
• 年：2014
• 卷：101
• 期：2
• 页码：545-551.e2
• 全文大小：1402 K

文摘

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Objective

To investigate the feasibility of using high-intensity focused ultrasound (HIFU), under dual-mode ultrasound arrays (DMUAs) guidance, to induce localized thermal damage inside ovaries without damage to the ovarian surface.

Design

Laboratory feasibility study.

Setting

University-based laboratory.

Animal(s)

Ex聽vivo canine and bovine ovaries.

Intervention(s)

DMUA-guided HIFU.

Main Outcome Measure(s)

Detection of ovarian damage by ultrasound imaging, gross pathology, and histology.

Result(s)

It is feasible to induce localized thermal damage inside ovaries without damage to the ovarian surface. DMUA provided sensitive imaging feedback regarding the anatomy of the treated ovaries and the ablation process. Different ablation protocols were tested, and thermal damage within the treated ovaries was histologically characterized.

Conclusion(s)

The absence of damage to the ovarian surface may eliminate many of the complications linked to current laparoscopic ovarian drilling (LOD) techniques. HIFU may be used as a less traumatic tool to perform LOD.