Alginate microgels loaded with temperature sensitive liposomes for magnetic resonance imageable drug release and microgel visualization
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- 作者：Merel van Elka ; Cyril Lorenzatob ; Burcin Ozbakira ; Chris Oerlemansb ; c ; Gert Storma ; Frank Nijsenc ; Roel Deckersb ; Tina Vermondena ; Wim E. Henninka ; W.E.Hennink@uu.nl" class="auth_mail" title="E-mail the corresponding author
- 关键词：MRI ; magnetic resonance imaging ; NTSL ; non-temperature sensitive liposomes ; TSL ; temperature sensitive liposomes ; Gd ; gadolinium ; [Gd(HPDO3A)(H2O)] ; Gd complex used as MRI contrast agent (Prohance® ; ) ; Ho ; holmium ; Ba ; barium ; NTSL-Ho-microgels ; holmium crosslinked microgels encapsulating NTSL ; TSL-Ho-microgels ; holmium crosslinked microgels encapsulating TSL ; TACE ; transarterial chemoembolization ; DEB ; drug eluting bead ; DSPC ; 1 ; 2-distearoyl-sn-glycero-3-phosphocholine ; DSPE-PEG2000 ; 1 ; 2-dist
- 刊名：European Polymer Journal
- 出版年：2015
- 出版时间：November 2015
- 年：2015
- 卷：72
- 期：Complete
- 页码：620-631
- 全文大小：1754 K
文摘
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Temperature sensitive liposomes were (TSL) were loaded with a dye and an MRI contrast agent.
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TSL were loaded into MR-imageable alginate microgels crosslinked with holmium ions.
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Microgels rapidly release the dye and MRI contrast agent upon hyperthermia (42 °C).
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Holmium crosslinked microgels were observed in an ex vivo kidney after injection.