Mycobacterial Toxin Induces Analgesia in Buruli Ulcer by Targeting the Angiotensin Pathways
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- 作者：Estelle Marion1 ; 2 ; 13 ; Ok-Ryul Song1 ; 2 ; 3 ; 13 ; Thierry Christophe2 ; 13 ; Jé ; ré ; mie Babonneau2 ; Denis Fenistein2 ; Joë ; l Eyer4 ; Frank Letournel4 ; Daniel Henrion5 ; Nicolas Clere6 ; Vincent Paille5 ; Nathalie C. Gué ; rineau5 ; Jean-Paul Saint André ; 7 ; Philipp Gersbach8 ; Karl-Heinz Altmann8 ; Timothy Paul Stinear9 ; Yannick Comoglio10 ; Guillaume Sandoz10 ; Laurence Preisser11 ; Yves Delneste11 ; Edouard Yeramian12 ; 14 ; Laurent Marsollier1 ; 2 ; 11 ; 14 ; laurent.marsollier@inserm.fr" class="auth_mail ; Priscille Brodin2 ; 3 ; 14 ; priscille.brodin@inserm.fr" class="auth_mail
- 刊名：Cell
- 出版年：19 June 2014
- 年：2014
- 卷：157
- 期：7
- 页码：1565-1576
- 全文大小：1927 K
文摘
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Buruli ulcer caused by Mycobacterium ulcerans is characterized by painless lesions
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Mycolactone produced by M. ulcerans induces hypoesthesia without nerve damage
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Pathway characterization pinpoints AT2R receptors as targets for mycolactone
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Model provides insight into implementation of analgesia in natural systems