Caryocar coriaceum Wittm. (Pequi) fixed oil presents hypolipemic and anti-inflammatory effects in vivo and in vitro

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• 作者：Patrí ; cia Rosane Leite de Figueiredo^a ; Isabella Bezerra Oliveira^a ; José ; Bení ; cio Santana Neto^a ; Juliana Albuquerque de Oliveira^a ; Larissa Bernardo Ribeiro^a ; Glauce Socorro de Barros Viana^a ; Talita Magalh&atilde ; es Rocha^b ; Luzia Kalyne Almeida Moreira Leal^b ; Marta Regina Kerntopf^c ; Cí ; cero Francisco Bezerra Felipe^d ; Henrique Douglas Melo Coutinho^e ; Irwin Rose de Alencar Menezes^c ; ^{irwinalencar@yahoo.com.br" class="auth_mail" title="E-mail the corresponding author} ; ^{irwin.alencar@urca.br" class="auth_mail" title="E-mail the corresponding author}
• 关键词：Caryocar coriaceum wittm ; Pequi ; Dyslipidemia ; Monounsaturated fatty acids ; Inflammation ; Myeloperoxidase
• 刊名：Journal of Ethnopharmacology
• 出版年：2016
• 出版时间：15 September 2016
• 年：2016
• 卷：191
• 期：Complete
• 页码：87-94
• 全文大小：1362 K

文摘

Caryocar coriaceum Wittm. (Pequi) is found in southern Ceará, where the fruit is used as food and in folk medicine as an anti-inflammatory, and to promote healing. However, little is known about the effects of repeated administration of its oil on the biochemical parameters of the blood. This work aimed to evaluate the effects Caryocar coriaceum fixed oil (OFCC); on the lipid profiles of healthy mice, on dyslipidemia induced by tyloxapol, and to study its anti-inflammatory effect both in vivo and in vitro. The results revealed significant reduction in total serum cholesterol and triglycerides, and an increase in HDL-C. The paw edema (induced by carrageenan) and myeloperoxidase (MPO), in polymorphonuclear culture cells, was reduced at all dose levels. Results demonstrated that Caryocar coriaceum's fix oil present anti-inflammatory activity and, for the first time describe the hypolipidemic effects, supporting its traditional use and suggest that present a potential cardioprotective effect.