Aminoguanidine treatment increased NOX2 response in diabetic rats: Improved phagocytosis and killing of Candida albicans by neutrophils
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- 作者：Clá ; udia de Souza Ferreiraa ; Paula Commune Pennacchia ; Tomaz Henrique Araú ; job ; Noemi Nosomi Taniwakic ; Fernanda Borges de Araú ; jo Paulaa ; Stella Maris da Silveira Duartea ; Maria Rita Rodriguesa ; mritar11@yahoo.com.br" class="auth_mail" title="E-mail the corresponding author
- 关键词：AGEs ; Advanced glycation end products ; AMG ; Aminoguanidine ; DM ; Diabetes mellitus ; HbA1c ; glycated hemoglobin ; HOCl ; hypochlorous acid ; NO ; Nitric oxide ; iNOS ; Nitric oxide synthase ; NOX2 ; phagocyte NADPH oxidase system ; ROS ; Reactive oxygen species ; ONOO- ; peroxynitrite ; PKC ; protein kinase C ; MPO ; myeloperoxidase
- 刊名：European Journal of Pharmacology
- 出版年：2016
- 出版时间：5 February 2016
- 年：2016
- 卷：772
- 期：Complete
- 页码：83-91
- 全文大小：1735 K
文摘
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The AMG increases the microbicidal activity of neutrophils against C. albicans
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The AMG modulates the response NOX2 against C. albicans
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Increased NOX2 by AMG was independent of the diabetic state and MPO activity.