Application of lanthanide catalysis in the penicillin to cephalosporin conversion

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• 作者：Barrett ; Anthony G. M. ; Christopher Braddock ; D. ; Cooper ; Robin D. G. ; Henschke ; Julian P.
• 关键词：ytterbium(III) triflate ; cephalosporin ; antibiotics ; sulfinyl carboxylate
• 刊名：Tetrahedron
• 出版年：2002
• 出版时间：October 7, 2002
• 年：2002
• 卷：58
• 期：41
• 页码：8313-8319
• 全文大小：173 K

文摘

seco-Penicillin sulfinyl carboxylates and chlorides were cyclized to produce the corresponding 3-methylenecepham systems, intermediates for cephalosporin antibiotic manufacture, either under thermal or ytterbium(III) triflate catalyzed conditions.