Neutralization Takes Precedence Over IgG or IgA Isotype-related Functions in Mucosal HIV-1 Antibody-mediated Protection

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• 作者：Rena D. Astronomo^a ; ¹ ; Sampa Santra^b ; ¹ ; Lamar Ballweber-Fleming^a ; Katharine G. Westerberg^a ; Linh Mach^b ; Tiffany Hensley-McBain^a ; Laura Sutherland^c ; Benjamin Mildenberg^b ; Georgeanna Morton^b ; Nicole L. Yates^c ; Gregory J. Mize^a ; Justin Pollara^c ; Florian Hladik^d ; ^a ; Christina Ochsenbauer^e ; Thomas N. Denny^c ; Ranjit Warrier^f ; Supachai Rerks-Ngarm^g ; Punnee Pitisuttithum^h ; Sorachai Nitayapanⁱ ; Jaranit Kaewkungwal^j ; Guido Ferrari^c ; George M. Shaw^f ; Shi-Mao Xia^c ; Hua-Xin Liao^c ; ² ; David C. Montefiori^c ; Georgia D. Tomaras^c ; Barton F. Haynes^c ; ³ ; M. Juliana McElrath^a ; ^k ; ^l ; ^m ; ³ ; ^{jmcelrat@fhcrc.org}
• 刊名：EBioMedicine
• 出版年：2016
• 出版时间：December 2016
• 年：2016
• 卷：14
• 期：Complete
• 页码：97-111
• 全文大小：2013 K
• 卷排序：14

文摘

Only broadly-neutralizing IgG and IgA Abs were protective in two relevant mucosal models of HIV-1 infection. IgG isotype variants were typically more protective than the IgA isotype variants against vaginal or rectal challenge. Neutralization rather than IgA-specific functions may afford better protection against mucosal HIV-1 infection.Antibodies are likely to play a key role in preventing HIV-1 infection following mucosal exposure. We used two mucosal models, in conjunction with IgG and IgA versions of the same antibodies, to identify protective antibody properties relevant to vaginal and rectal transmission. Antibodies that can potently neutralize most HIV-1 strains were protective against viral challenge, but those without this capability were non-protective. The IgA antibodies were no more protective than their IgG counterparts even though IgA antibody forms are more abundant in the mucosa. These findings can help prioritize vaccine designs to those that induce potent broadly neutralizing IgG antibodies.