Genetic variants in the regulatory region of SLC10A1 are not associated with the risk of hepatitis B virus infection and clearance
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- 作者：Xueqin Chena ; c ; 1 ; Ying Wangb ; 1 ; Xiaohua Chend ; Kailiang Chenge ; Jiaoyuan Lia ; Jiao Loua ; Juntao Kea ; Yang Yanga ; Yajie Gonga ; Ying Zhua ; Li Wange ; liwang@ibms.pumc.edu.cn" class="auth_mail" title="E-mail the corresponding author ; Rong Zhonga ; rongzhong91@gmail.com" class="auth_mail" title="E-mail the corresponding author
- 关键词：Regulatory variants ; Hepatitis B virus ; Cellular receptor ; Susceptibility ; Clearance
- 刊名：Infection, Genetics and Evolution
- 出版年：2016
- 出版时间：October 2016
- 年：2016
- 卷：44
- 期：Complete
- 页码：495-500
- 全文大小：361 K
文摘
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A design comprised HBV carriers/natural clearance subjects as infected group and HBV negative subjects as uninfected group.
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No significant effects of potentially regulatory variants in SLC10A1 on HBV infection and clearance were observed.
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Functional studies in vitro and ex vivo have provided no evidence for the role of NTCP genetic variants in regulating protein expression levels.