Micropatterned coculture of hepatocytes on electrospun fibers as a potential in vitro model for predictive drug metabolism
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- 作者：Yaowen Liua ; b ; Jiaojun Weia ; Jinfu Lua ; Dongmei Leia ; Shili Yana ; Xiaohong Lia ; xhli@swjtu.edu.cn" class="auth_mail" title="E-mail the corresponding author
- 关键词：Micropatterned fibrous mats ; Hepatocyte coculture ; Hepatocyte spheroid ; Drug metabolism ; Drug-drug interaction
- 刊名：Materials Science & Engineering C
- 出版年：2016
- 出版时间：1 June 2016
- 年：2016
- 卷：63
- 期：Complete
- 页码：475-484
- 全文大小：1533 K
文摘
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Micropatterned coculture of hepatocytes is established on fibrous scaffolds.
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Multicellular hepatocyte spheroids are formed to maintain liver-specific functions.
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Activities of metabolizing enzymes are maintained throughout 15 days of culture.
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In vitro predicting drug clearance rates show good correlations with in vivo data.
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Drug-drug interactions exhibit in vivo-in vitro correlations to a certain extent.