Comparison of the transcriptomic profile of hepatic human induced pluripotent stem like cells cultured in plates and in a 3D microscale dynamic environment
We performed iPS hepatic like cells culture in a microfluidic biochip. We compared the transcriptomic profiles from biochips and plated cultures. We found higher hepatic differentiation patterns in biochips. We measured higher functional liver like activities in biochips. Although encouraging results, the biochip cultures remained a liver fœtal stage.